COPS4

Across TCGA patient cohorts, COPS4 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS4-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ERK2. Each is linked with COPS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS4-to-partner and partner-to-COPS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by COPS4-low versus COPS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS4→partner) and Y-score (partner→COPS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.113	-2.973	.019	.035	3	1
UCEC	A-Raf_pS299 →	-0.141	-2.321	.014	.034	3	1
UCEC	ERK2 →	+0.184	+3.169	.047	.019	3	1
UCEC	IRS1 →	+0.360	+2.459	<.001	.020	3	1
UCEC	MEK1 →	+0.433	+2.459	.014	.020	3	1
UCEC	Rab25 →	-0.432	-3.000	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

14-3-3_beta by COPS4 expression — UCEC

Explore this box plot interactively →