COPS4

Across TCGA cell cohorts, COPS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,711 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COPS4-associated GO terms across cancer lineages are Protein neddylation, DAMP biosynthetic process, and Purine deoxyribonucleoside monophosphate biosynthetic process. Each is linked with COPS4 in more than 15 cancer types. Because this analysis shows association rather than direction, both COPS4-to-partner and partner-to-COPS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein neddylation grouped by COPS4-low versus COPS4-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS4→partner) and Y-score (partner→COPS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein neddylation →	+0.125	+0.662	.003	.005	3	16
KIDNEY	DAMP biosynthetic process →	+0.151	+0.522	<.001	<.001	3	15
KIDNEY	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.151	+0.522	<.001	<.001	3	15
URINARY_TRACT	Kinetochore assembly →	+0.130	+0.605	.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome segregation →	+0.101	+0.849	.003	.007	3	14
PANCREAS	Mitotic nuclear division →	+0.094	+0.908	<.001	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,711 associations by consensus.

Protein neddylation by COPS4 expression — LIVER

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