COPS4

Across TCGA cell cohorts, COPS4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COPS4-associated genes across cancer lineages are C9orf92, OR4F5, and GSG1L2. Each is linked with COPS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS4-to-partner and partner-to-COPS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by COPS4-low versus COPS4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS4→partner) and Y-score (partner→COPS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.194	+5.369	<.001	.004	3	1
LARGE_INTESTINE	OR4F5 →	+0.024	+3.345	<.001	.007	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1
BLOOD_Lymphoma	TRIM60 →	+0.345	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C9orf92 by COPS4 expression — SOFT_TISSUE

Explore this box plot interactively →