COPS3

Across TCGA pan-cancer cohorts, COPS3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COPS3 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher COPS3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COPS3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

LUAD, HNSC, and UCEC are the cancer types where COPS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.247	0.805	.001	26	view →
HNSC	DFS	Quartile	II,III,IV	0.891	1.000	.006	23	view →
UCEC	DFS	Median	All	0.933	0.780	.019	18	view →
CCRCC	DFS	Quartile	All	1.000	0.475	.023	7	view →
PDAC	OS	Quartile	IV	0.911	0.394	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COPS3–LUAD (DFS)

Open the LUAD breakdown →