COPS3

Across TCGA patient cohorts, COPS3 mutation is significantly associated with the RNA expression of many other genes, with 1,707 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS3-associated genes across cancer lineages are RNA5SP325, RPS29P32, and RNA5SP388. Each is linked with COPS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both COPS3-to-partner and partner-to-COPS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP325 grouped by COPS3-low versus COPS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS3→partner) and Y-score (partner→COPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP325 →	+0.799	+1.765	<.001	.005	3	3
UCEC	RPS29P32 →	+0.478	+2.500	<.001	<.001	3	2
LUAD	RNA5SP388 →	+0.513	+7.930	<.001	.008	3	2
UCEC	MIR425 →	+0.376	+2.107	<.001	.001	3	2
BRCA	RNU6-990P →	+2.027	+6.234	<.001	<.001	3	2
UCEC	MIR4445 →	+0.146	+4.156	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

RNA5SP325 by COPS3 expression — UCEC

Explore this box plot interactively →