COPS3

Across TCGA cell cohorts, COPS3 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COPS3-associated genes across cancer lineages are MT1B, OR51A4, and SMIM28. Each is linked with COPS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS3-to-partner and partner-to-COPS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT1B grouped by COPS3-low versus COPS3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS3→partner) and Y-score (partner→COPS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MT1B →	+0.103	+5.415	<.001	.004	3	1
SKIN	OR51A4 →	+0.013	+6.022	<.001	.001	3	1
SKIN	SMIM28 →	+0.026	+6.022	<.001	.001	3	1
BLOOD_Leukemia	SLC32A1 →	+0.619	+3.901	<.001	.006	3	1
BLOOD_Leukemia	EPPIN →	+0.005	+4.507	.001	.001	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MT1B by COPS3 expression — SKIN

Explore this box plot interactively →