COPS2

Across TCGA patient cohorts, COPS2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,792 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible COPS2-associated genes across cancer lineages are MTERF4, NRDE2, and SGSM2. Each is linked with COPS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both COPS2-to-partner and partner-to-COPS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COPS2 versus MTERF4 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS2→partner) and Y-score (partner→COPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTERF4 →	+0.444	+0.221	<.001	<.001	3	4
LUAD	NRDE2 →	+0.340	+0.135	<.001	<.001	3	3
BRCA	SGSM2 →	+0.638	+0.190	.002	<.001	3	3
BRCA	TMEM91 →	+0.678	+0.152	<.001	.007	3	3
LSCC	PDZK1IP1 →	-1.116	-0.113	.004	.001	3	3
BRCA	HENMT1 →	-0.939	-0.216	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,792 associations by consensus.

COPS2 vs MTERF4 — BRCA

Explore this scatter interactively →