COPS2

Across TCGA patient cohorts, COPS2 mutation is significantly associated with the RNA expression of many other genes, with 2,797 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS2-associated genes across cancer lineages are SNRPGP7, FKBP4P7, and LINC01880. Each is linked with COPS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both COPS2-to-partner and partner-to-COPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP7 grouped by COPS2-low versus COPS2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS2→partner) and Y-score (partner→COPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SNRPGP7 →	+0.462	+5.473	<.001	<.001	3	3
LUAD	FKBP4P7 →	+0.048	+3.962	<.001	.005	3	2
READ	LINC01880 →	+0.137	+5.421	<.001	.005	3	2
READ	LINC00458 →	+0.030	+5.039	<.001	.008	3	2
STAD	RPL7AP23 →	+0.157	+4.564	<.001	<.001	3	2
UCEC	TEX43 →	+0.165	+1.799	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,797 associations by consensus.

SNRPGP7 by COPS2 expression — LUAD

Explore this box plot interactively →