COPS2

Across TCGA patient cohorts, COPS2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPS2-associated genes across cancer lineages are TFRC, CD31, and 4E-BP1. Each is linked with COPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS2-to-partner and partner-to-COPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by COPS2-low versus COPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS2→partner) and Y-score (partner→COPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.496	+3.169	.014	.018	3	2
UCEC	CD31 →	-0.118	-1.990	.037	.030	3	2
UCEC	4E-BP1 →	+0.410	+2.730	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.102	-2.432	.008	.018	3	1
UCEC	EGFR_pY1068 →	-0.218	-2.459	.023	.019	3	1
UCEC	Heregulin →	-0.143	-2.700	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TFRC by COPS2 expression — UCEC

Explore this box plot interactively →