COPS2

Across TCGA cell cohorts, COPS2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COPS2-associated genes across cancer lineages are NUTF2, KDELR1, and CRYZ. Each is linked with COPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPS2-to-partner and partner-to-COPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NUTF2 grouped by COPS2-low versus COPS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS2→partner) and Y-score (partner→COPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NUTF2 →	+0.522	+3.251	.002	.006	3	1
LARGE_INTESTINE	KDELR1 →	+0.676	+3.087	<.001	.006	3	1
LARGE_INTESTINE	CRYZ →	+0.910	+3.169	.005	.005	3	1
LARGE_INTESTINE	PGRMC2 →	+0.701	+3.087	.001	.006	3	1
LARGE_INTESTINE	SLN →	+0.117	+3.929	.009	<.001	3	1
LARGE_INTESTINE	ACOT12 →	+0.038	+2.672	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

NUTF2 by COPS2 expression — LARGE_INTESTINE

Explore this box plot interactively →