COPS2

Across TCGA cell cohorts, COPS2 mutation is significantly associated with the mutation status of many other genes, with 3,733 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COPS2-associated genes across cancer lineages are TUT7, SLC25A31, and PMS2. Each is linked with COPS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both COPS2-to-partner and partner-to-COPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUT7 grouped by COPS2-low versus COPS2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPS2→partner) and Y-score (partner→COPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TUT7 →	+4.954	+4.392	.008	.008	1	4
BLOOD_Leukemia	SLC25A31 →	+4.736	+5.560	.003	.003	1	4
LARGE_INTESTINE	PMS2 →	+2.807	+3.321	<.001	<.001	1	4
BLOOD_Leukemia	MARK1 →	+4.000	+5.050	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	NAA15 →	+4.954	+4.392	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	PTCHD1 →	+4.954	+4.392	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,733 associations by consensus.

TUT7 by COPS2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →