COPRS

Across TCGA pan-cancer cohorts, COPRS mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated COPRS data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COPRS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COPRS expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, OV, and HNSC are the cancer types where COPRS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	1.000	0.795	.015	16	view →
OV	DFS	Median	All	0.659	0.942	.011	8	view →
HNSC	DFS	Quartile	All	0.205	1.000	.024	6	view →
LUAD	OS	Tertile	II,III,IV	0.757	0.378	.018	4	view →
GBM	DFS	Median	All	0.659	0.771	.015	4	view →
PDAC	DFS	Tertile	II,III,IV	0.678	0.914	.013	2	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

COPRS–UCEC (DFS)

Open the UCEC breakdown →