COPRS

Across TCGA patient cohorts, COPRS mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPRS-associated genes across cancer lineages are EGFR_pY1068, Rab25, and STAT3_pY705. Each is linked with COPRS in more than 1 cancer types. Because this analysis shows association rather than direction, both COPRS-to-partner and partner-to-COPRS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by COPRS-low versus COPRS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPRS→partner) and Y-score (partner→COPRS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.307	-3.000	.019	.036	3	1
UCEC	Rab25 →	-0.519	-3.321	.002	.010	3	1
UCEC	STAT3_pY705 →	-0.452	-2.999	<.001	.035	3	1
UCEC	Tuberin →	+0.452	+3.321	.001	.010	3	1
UCEC	VEGFR2 →	+0.410	+2.183	.008	.035	3	1
UCEC	VHL →	-1.276	-3.000	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by COPRS expression — UCEC

Explore this box plot interactively →