COPG2

Across TCGA patient cohorts, COPG2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPG2-associated genes across cancer lineages are Cyclin-B1, FASN, and JNK2. Each is linked with COPG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPG2-to-partner and partner-to-COPG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by COPG2-low versus COPG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPG2→partner) and Y-score (partner→COPG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.663	+3.000	.014	.036	3	2
UCEC	FASN →	+0.390	+2.459	.040	.020	3	1
UCEC	JNK2 →	+0.268	+2.459	.005	.020	3	1
UCEC	PCNA →	+0.292	+2.999	.005	.035	3	1
UCEC	STAT3_pY705 →	-0.571	-3.584	<.001	.002	3	1
UCEC	TFRC →	+0.667	+2.459	.009	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Cyclin-B1 by COPG2 expression — UCEC

Explore this box plot interactively →