COPG1

Across TCGA patient cohorts, COPG1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. COAD shows the largest number of these associations.

The most reproducible COPG1-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and TSC1. Each is linked with COPG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COPG1-to-partner and partner-to-COPG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by COPG1-low versus COPG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPG1→partner) and Y-score (partner→COPG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.673	+2.720	.004	.003	3	3
UCEC	Cyclin-B1 →	+0.486	+1.906	.031	.016	3	2
COAD	TSC1 →	-0.400	-2.991	.005	.036	3	2
COAD	ASNS →	+0.881	+3.008	<.001	.019	2	3
UCEC	14-3-3_beta →	-0.086	-2.973	.033	.035	3	1
UCEC	HER2_pY1248 →	-0.213	-3.087	.047	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by COPG1 expression — UCEC

Explore this box plot interactively →