Across TCGA patient cohorts, COPB2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPB2-associated genes across cancer lineages are FoxM1, ACC1, and Rab11. Each is linked with COPB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPB2-to-partner and partner-to-COPB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPB2→partner) and Y-score (partner→COPB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.272	+2.321	.001	<.001	3	2
UCEC	ACC1 →	+0.292	+1.222	.013	.035	3	2
UCEC	Rab11 →	-0.139	-2.807	.003	.002	3	2
UCEC	Rad50 →	-0.298	-2.321	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.159	-1.459	.001	.012	3	2
UCEC	STAT3_pY705 →	-0.459	-2.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

COPB2 survival (RNA) · tumor vs normal (RNA) · all COPB2 data types