Across TCGA cell cohorts, COPB2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COPB2-associated genes across cancer lineages are OR2K2, OR2A4, and FOXI2. Each is linked with COPB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COPB2-to-partner and partner-to-COPB2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPB2→partner) and Y-score (partner→COPB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2K2 →	+0.024	+4.095	.009	.009	3	1
LARGE_INTESTINE	OR2A4 →	+0.095	+4.095	<.001	.009	3	1
LARGE_INTESTINE	FOXI2 →	+0.024	+5.217	<.001	<.001	3	1
BLOOD_Leukemia	CCL8 →	+0.050	+4.705	<.001	.003	3	1
BLOOD_Leukemia	SLC36A2 →	+0.023	+4.551	<.001	.004	3	1
BLOOD_Leukemia	TCP11X2 →	+0.151	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

COPB2 survival (RNA) · tumor vs normal (RNA) · all COPB2 data types