COPA

Across TCGA pan-cancer cohorts, COPA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COPA data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher COPA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COPA expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where COPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.385	0.933	.001	18	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →
GBM	DFS	Quartile	All	0.690	0.843	.019	2	view →
LUAD	DFS	Median	All	0.934	0.865	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COPA–LSCC (DFS)

Open the LSCC breakdown →