COPA

Across TCGA patient cohorts, COPA mutation is significantly associated with the RNA expression of many other genes, with 4,277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPA-associated genes across cancer lineages are RNA5SP65, MIR6801, and PSMC3IP. Each is linked with COPA in more than 3 cancer types. Because this analysis shows association rather than direction, both COPA-to-partner and partner-to-COPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP65 grouped by COPA-low versus COPA-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPA→partner) and Y-score (partner→COPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA5SP65 →	+0.421	+4.257	<.001	<.001	3	4
CESC	MIR6801 →	+0.548	+4.007	.001	.003	3	3
UCEC	PSMC3IP →	+0.508	+1.635	<.001	<.001	3	3
UCEC	EIF2B1 →	+0.300	+1.645	<.001	<.001	3	3
UCEC	ENO2 →	+0.488	+1.525	.005	.008	3	3
UCEC	TMEM131L →	+0.456	+2.064	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,277 associations by consensus.

RNA5SP65 by COPA expression — STAD

Explore this box plot interactively →