COPA

Across TCGA patient cohorts, COPA mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COPA-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and eIF4E. Each is linked with COPA in more than 3 cancer types. Because this analysis shows association rather than direction, both COPA-to-partner and partner-to-COPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by COPA-low versus COPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPA→partner) and Y-score (partner→COPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.410	+1.777	<.001	.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.462	+2.169	.005	.002	3	4
UCEC	eIF4E →	+0.174	+2.920	.003	<.001	3	3
UCEC	FASN →	+0.259	+1.106	.019	.020	3	3
UCEC	ATM →	-0.459	-1.912	<.001	.004	3	3
UCEC	Bak →	+0.170	+1.925	.015	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

ASNS by COPA expression — UCEC

Explore this box plot interactively →