COPA

Across TCGA cell cohorts, COPA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,774 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible COPA-associated GO terms across cancer lineages are Endosomal transport, Cytosolic transport, and Golgi vesicle transport. Each is linked with COPA in more than 14 cancer types. Because this analysis shows association rather than direction, both COPA-to-partner and partner-to-COPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by COPA-low versus COPA-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COPA→partner) and Y-score (partner→COPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Endosomal transport →	+0.063	+1.054	<.001	<.001	3	15
LARGE_INTESTINE	Cytosolic transport →	+0.068	+0.964	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.059	+0.810	.001	<.001	3	13
SOFT_TISSUE	Vesicle-mediated transport to the plasma membrane →	+0.055	+1.052	<.001	<.001	3	13
BLOOD_Lymphoma	Negative regulation of PERK-mediated unfolded protein response →	+0.132	+1.260	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of translational initiation →	+0.075	+0.727	.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,774 associations by consensus.

Endosomal transport by COPA expression — SOFT_TISSUE

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