COPA

Across TCGA cell cohorts, COPA mutation is significantly associated with the RNA expression of many other genes, with 542 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COPA-associated genes across cancer lineages are ADAM7, IQCM, and OR2B2. Each is linked with COPA in more than 2 cancer types. Because this analysis shows association rather than direction, both COPA-to-partner and partner-to-COPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by COPA-low versus COPA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COPA→partner) and Y-score (partner→COPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.003	+2.667	<.001	<.001	3	3
PANCREAS	IQCM →	+0.102	+5.000	<.001	.006	3	2
OVARY	OR2B2 →	+0.040	+3.938	<.001	.005	3	2
KIDNEY	LCE3D →	+0.110	+5.000	<.001	.005	3	1
KIDNEY	OR10H5 →	+0.013	+5.000	<.001	.005	3	1
KIDNEY	KRTAP13-2 →	+0.026	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 542 associations by consensus.

ADAM7 by COPA expression — LARGE_INTESTINE

Explore this box plot interactively →