COP1

Across TCGA pan-cancer cohorts, COP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated COP1 data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher COP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated COP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where COP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	1.000	0.331	.008	13	view →
LUAD	DFS	Tertile	All	0.900	0.981	.025	7	view →
PDAC	OS	Quartile	All	0.927	0.616	.022	6	view →
GBM	DFS	Median	All	0.828	0.557	.019	5	view →
CCRCC	DFS	Tertile	All	0.911	0.600	.042	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

COP1–HNSC (DFS)

Open the HNSC breakdown →