COP1

Across TCGA patient cohorts, COP1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,724 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible COP1-associated genes across cancer lineages are TMEM248, DDX59, and CAMSAP2. Each is linked with COP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COP1-to-partner and partner-to-COP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COP1 versus TMEM248 in LUAD, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COP1→partner) and Y-score (partner→COP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TMEM248 →	+0.339	+0.163	.001	.002	3	3
LSCC	DDX59 →	+0.482	+0.179	<.001	<.001	3	3
LSCC	CAMSAP2 →	+0.510	+0.130	.003	.005	3	3
UCEC	SCARNA3 →	+0.643	+0.169	.003	.004	3	3
UCEC	KYNU →	-0.800	-0.274	.005	.003	3	2
LSCC	FAM20B →	+0.473	+0.128	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,724 associations by consensus.

COP1 vs TMEM248 — LUAD

Explore this scatter interactively →