COP1

Across TCGA patient cohorts, COP1 mutation is significantly associated with the RNA expression of many other genes, with 2,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COP1-associated genes across cancer lineages are TSPOAP1, ORC1, and NBEAP5. Each is linked with COP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COP1-to-partner and partner-to-COP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPOAP1 grouped by COP1-low versus COP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COP1→partner) and Y-score (partner→COP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSPOAP1 →	-0.668	-1.643	<.001	.003	3	3
UCEC	ORC1 →	+0.528	+2.016	.003	.001	3	3
LIHC	NBEAP5 →	+0.168	+4.758	<.001	.006	3	2
CESC	RNA5SP162 →	+0.771	+5.103	<.001	.008	3	2
SKCM	CAMTA1-AS2 →	+0.049	+3.232	<.001	.002	3	2
SKCM	RPL32P9 →	+0.250	+2.479	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,586 associations by consensus.

TSPOAP1 by COP1 expression — UCEC

Explore this box plot interactively →