COP1

Across TCGA patient cohorts, COP1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COP1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, FOXO3a_pS318_S321, and mTOR_pS2448. Each is linked with COP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both COP1-to-partner and partner-to-COP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by COP1-low versus COP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COP1→partner) and Y-score (partner→COP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.422	-1.502	.007	.027	3	3
UCEC	FOXO3a_pS318_S321 →	-0.101	-2.000	.021	.003	3	2
UCEC	mTOR_pS2448 →	-0.172	-2.893	.001	.001	3	2
UCEC	PCNA →	+0.227	+2.584	.002	.010	3	2
UCEC	PDCD4 →	-0.482	-2.312	.003	.005	3	2
UCEC	Rad50 →	-0.204	-2.115	.017	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

p38-MAPK_pT180_Y182 by COP1 expression — UCEC

Explore this box plot interactively →