COP1

Across TCGA cell cohorts, COP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,322 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible COP1-associated GO terms across cancer lineages are Establishment of protein localization to endoplasmic reticulum membrane, Nuclear pore organization, and Positive regulation of ATP-dependent activity. Each is linked with COP1 in more than 11 cancer types. Because this analysis shows association rather than direction, both COP1-to-partner and partner-to-COP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to endoplasmic reticulum membrane grouped by COP1-low versus COP1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COP1→partner) and Y-score (partner→COP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Establishment of protein localization to endoplasmic reticulum membrane →	+0.131	+0.729	.003	.003	2	12
UPPER_AERODIGESTIVE_TRACT	Nuclear pore organization →	+0.160	+0.679	<.001	<.001	3	10
KIDNEY	Positive regulation of ATP-dependent activity →	+0.111	+0.571	.001	.004	3	9
STOMACH	mRNA 3'-end processing →	+0.077	+0.419	.002	.002	3	9
LUNG_NSCLC_LUSC	Positive regulation of chromatin organization →	+0.110	+0.629	.004	.002	3	8
SOFT_TISSUE	Regulation of stem cell population maintenance →	+0.061	+0.558	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,322 associations by consensus.

Establishment of protein localization to endoplasmic reticulum membrane by COP1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →