COP1

Across TCGA cell cohorts, COP1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible COP1-associated genes across cancer lineages are OR12D3, DEFB123, and CRYGB. Each is linked with COP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both COP1-to-partner and partner-to-COP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D3 grouped by COP1-low versus COP1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COP1→partner) and Y-score (partner→COP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR12D3 →	+0.005	+4.643	<.001	.004	3	1
LUNG_SCLC	DEFB123 →	+0.077	+4.643	<.001	.004	3	1
LUNG_SCLC	CRYGB →	+0.062	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR51Q1 →	+0.092	+2.603	.001	.009	3	1
LUNG_NSCLC_LUAD	GNG8 →	+0.162	+3.150	.002	.006	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR12D3 by COP1 expression — LUNG_SCLC

Explore this box plot interactively →