COMTD1

Across TCGA patient cohorts, COMTD1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,460 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible COMTD1-associated genes across cancer lineages are FZD2, ARMCX1, and DTX3. Each is linked with COMTD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both COMTD1-to-partner and partner-to-COMTD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COMTD1 versus FZD2 in OV, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMTD1→partner) and Y-score (partner→COMTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FZD2 →	-0.838	-0.423	.004	.001	3	5
BRCA	ARMCX1 →	-0.858	-0.477	<.001	<.001	3	4
UCEC	DTX3 →	-0.749	-0.338	.004	.004	1	6
LSCC	VDAC2 →	+0.699	+0.473	<.001	<.001	3	4
BRCA	ZNF230 →	-0.379	-0.346	.002	.002	3	4
HNSC	ZEB2 →	-0.602	-0.332	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,460 associations by consensus.

COMTD1 vs FZD2 — OV

Explore this scatter interactively →