COMTD1

Across TCGA cell cohorts, COMTD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,675 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible COMTD1-associated GO terms across cancer lineages are Energy coupled proton transmembrane transport, against electrochemical gradient, Electron transport coupled proton transport, and Collagen fibril organization. Each is linked with COMTD1 in more than 11 cancer types. Because this analysis shows association rather than direction, both COMTD1-to-partner and partner-to-COMTD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Energy coupled proton transmembrane transport, against electrochemical gradient grouped by COMTD1-low versus COMTD1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMTD1→partner) and Y-score (partner→COMTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.066	+0.935	.001	.002	3	12
SKIN	Electron transport coupled proton transport →	+0.066	+0.935	.001	.002	3	12
BREAST	Collagen fibril organization →	-0.191	-1.234	.001	<.001	3	11
BREAST	Regulation of cellular hyperosmotic salinity response →	+0.174	+1.198	<.001	.005	3	11
BREAST	Regulation of response to salt stress →	+0.174	+1.198	<.001	.005	3	11
BLOOD_Leukemia	Regulation of collagen metabolic process →	-0.129	-0.961	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,675 associations by consensus.

Energy coupled proton transmembrane transport, against electrochemical gradient by COMTD1 expression — SKIN

Explore this box plot interactively →