COMP

Across TCGA patient cohorts, COMP mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMP-associated genes across cancer lineages are ATM, INPP4B, and RAD51. Each is linked with COMP in more than 3 cancer types. Because this analysis shows association rather than direction, both COMP-to-partner and partner-to-COMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by COMP-low versus COMP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMP→partner) and Y-score (partner→COMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.635	-2.000	.001	.032	3	4
UCEC	INPP4B →	-0.363	-3.321	.012	.009	3	2
UCEC	RAD51 →	+0.173	+2.000	.005	.032	3	2
UCEC	Shc_pY317 →	-0.235	-2.000	<.001	.032	3	2
UCEC	VHL →	-0.912	-3.321	.002	.010	3	2
UCEC	FoxM1 →	+0.283	+2.999	.015	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by COMP expression — UCEC

Explore this box plot interactively →