COMP

Across TCGA cell cohorts, COMP RNA expression is significantly associated with the go_rna of many other GO terms, with 1,014 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible COMP-associated GO terms across cancer lineages are Regulation of DNA repair, Aromatic amino acid metabolic process, and Protein sumoylation. Each is linked with COMP in more than 5 cancer types. Because this analysis shows association rather than direction, both COMP-to-partner and partner-to-COMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by COMP-low versus COMP-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMP→partner) and Y-score (partner→COMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of DNA repair →	+0.023	+0.170	.004	.001	3	6
SKIN	Aromatic amino acid metabolic process →	-0.245	-0.171	<.001	<.001	3	6
SKIN	Protein sumoylation →	+0.032	+0.140	<.001	.001	3	5
SKIN	Microtubule cytoskeleton organization involved in mitosis →	+0.053	+0.118	.007	.009	3	5
LARGE_INTESTINE	Negative regulation of gene expression, epigenetic →	+0.038	+0.273	.001	.007	3	5
SKIN	Mitochondrial electron transport, ubiquinol to cytochrome c →	+0.046	+0.133	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,014 associations by consensus.

Regulation of DNA repair by COMP expression — SKIN

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