COMP

Across TCGA cell cohorts, COMP mutation is significantly associated with the RNA expression of many other genes, with 464 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible COMP-associated genes across cancer lineages are OR7D4, RBMY1J, and OR10G2. Each is linked with COMP in more than 1 cancer types. Because this analysis shows association rather than direction, both COMP-to-partner and partner-to-COMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7D4 grouped by COMP-low versus COMP-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMP→partner) and Y-score (partner→COMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR7D4 →	+0.056	+5.196	<.001	.005	3	1
OVARY	RBMY1J →	+0.023	+5.807	<.001	.001	3	1
OVARY	OR10G2 →	+0.026	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPINT4 →	+0.047	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	NANOGNB →	+0.135	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	HIGD1C →	+0.084	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 464 associations by consensus.

OR7D4 by COMP expression — OVARY

Explore this box plot interactively →