COMMD9

Across TCGA pan-cancer cohorts, COMMD9 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COMMD9 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COMMD9 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COMMD9 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

COAD, PDAC, and UCEC are the cancer types where COMMD9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.835	1.000	.033	12	view →
PDAC	DFS	Tertile	All	0.465	0.317	.027	4	view →
UCEC	OS	Tertile	II,III,IV	0.651	1.000	.049	4	view →
GBM	OS	Median	All	0.661	0.864	.039	2	view →
HNSC	DFS	Tertile	III,IV	0.920	0.720	.043	1	view →
LSCC	OS	Quartile	All	0.818	1.000	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COMMD9–COAD (DFS)

Open the COAD breakdown →