COMMD9

Across TCGA cell cohorts, COMMD9 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,841 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible COMMD9-associated GO terms across cancer lineages are Regulation of cellular response to osmotic stress, Interleukin-17A-mediated signaling pathway, and Regulation of response to osmotic stress. Each is linked with COMMD9 in more than 9 cancer types. Because this analysis shows association rather than direction, both COMMD9-to-partner and partner-to-COMMD9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cellular response to osmotic stress grouped by COMMD9-low versus COMMD9-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD9→partner) and Y-score (partner→COMMD9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of cellular response to osmotic stress →	+0.122	+1.278	.003	.001	2	10
KIDNEY	Interleukin-17A-mediated signaling pathway →	+0.093	+0.679	<.001	<.001	3	9
OESOPHAGUS	Regulation of response to osmotic stress →	+0.163	+0.902	.001	.002	2	10
URINARY_TRACT	Protein to membrane docking →	+0.114	+1.097	<.001	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Response to mitochondrial depolarisation →	+0.098	+0.912	.003	.003	2	9
BREAST	Negative regulation of CD4-positive, alpha-beta T cell activation →	-0.125	-1.206	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,841 associations by consensus.

Regulation of cellular response to osmotic stress by COMMD9 expression — BLOOD_Myeloma

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