COMMD8

Across TCGA pan-cancer cohorts, COMMD8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COMMD8 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher COMMD8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COMMD8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, CCRCC, and GBM are the cancer types where COMMD8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.895	1.000	.019	78	view →
CCRCC	OS	Tertile	All	1.000	0.569	.013	9	view →
GBM	OS	Quartile	All	0.652	0.957	.042	3	view →
HNSC	OS	Median	II,III,IV	0.901	0.809	.039	2	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.498	.040	1	view →
PDAC	DFS	Tertile	III,IV	0.575	0.928	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COMMD8–COAD (DFS)

Open the COAD breakdown →