COMMD8

Across TCGA patient cohorts, COMMD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,163 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible COMMD8-associated GO terms across cancer lineages are Error-free translesion synthesis, Interstrand cross-link repair, and Regulation of centriole replication. Each is linked with COMMD8 in more than 24 cancer types. Because this analysis shows association rather than direction, both COMMD8-to-partner and partner-to-COMMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Error-free translesion synthesis grouped by COMMD8-low versus COMMD8-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD8→partner) and Y-score (partner→COMMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Error-free translesion synthesis →	+0.074	+0.826	<.001	<.001	3	25
ACC	Interstrand cross-link repair →	+0.056	+1.167	<.001	<.001	3	25
UVM	Regulation of centriole replication →	+0.069	+1.932	<.001	<.001	3	25
ACC	Positive regulation of chromosome separation →	+0.118	+1.131	<.001	<.001	2	25
ACC	Positive regulation of chromosome condensation →	+0.121	+1.033	<.001	<.001	2	25
UCS	Regulation of chromosome condensation →	+0.094	+0.792	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,163 associations by consensus.

Error-free translesion synthesis by COMMD8 expression — UCS

Explore this box plot interactively →