COMMD8

Across TCGA patient cohorts, COMMD8 protein abundance is significantly associated with the RNA expression of many other genes, with 6,771 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible COMMD8-associated genes across cancer lineages are ADGRE4P, CD33, and NPHP3. Each is linked with COMMD8 in more than 3 cancer types. Because this analysis shows association rather than direction, both COMMD8-to-partner and partner-to-COMMD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COMMD8 versus ADGRE4P in LUAD, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD8→partner) and Y-score (partner→COMMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADGRE4P →	+0.565	+0.147	<.001	<.001	3	4
LUAD	CD33 →	+0.420	+0.138	<.001	<.001	3	3
BRCA	NPHP3 →	+0.379	+0.185	.002	.002	3	3
LUAD	NEK1 →	+0.457	+0.163	<.001	<.001	3	3
BRCA	ZMYM6 →	+0.453	+0.245	<.001	<.001	3	3
UCEC	ETFDH →	+0.670	+0.242	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,771 associations by consensus.

COMMD8 vs ADGRE4P — LUAD

Explore this scatter interactively →