COMMD8

Across TCGA patient cohorts, COMMD8 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD8-associated genes across cancer lineages are RNA5SP421, RNU1-105P, and RNU4ATAC7P. Each is linked with COMMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD8-to-partner and partner-to-COMMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP421 grouped by COMMD8-low versus COMMD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD8→partner) and Y-score (partner→COMMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP421 →	+1.285	+2.925	<.001	.003	3	2
LUSC	RNU1-105P →	+0.267	+6.309	<.001	.001	3	2
BRCA	RNU4ATAC7P →	+0.222	+8.055	<.001	.007	3	1
BRCA	TTTY8B →	+0.044	+8.055	<.001	.007	3	1
BRCA	RNU6-755P →	+1.027	+7.731	<.001	.009	3	1
BRCA	MTATP6P30 →	+0.054	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

RNA5SP421 by COMMD8 expression — UCEC

Explore this box plot interactively →