COMMD8

Across TCGA cell cohorts, COMMD8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,486 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible COMMD8-associated GO terms across cancer lineages are 7-methylguanosine mRNA capping, 7-methylguanosine RNA capping, and Protein localization to condensed chromosome. Each is linked with COMMD8 in more than 11 cancer types. Because this analysis shows association rather than direction, both COMMD8-to-partner and partner-to-COMMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 7-methylguanosine mRNA capping grouped by COMMD8-low versus COMMD8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD8→partner) and Y-score (partner→COMMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	7-methylguanosine mRNA capping →	+0.076	+0.833	.003	.003	3	12
UPPER_AERODIGESTIVE_TRACT	7-methylguanosine RNA capping →	+0.076	+0.833	.003	.003	3	12
OESOPHAGUS	Protein localization to condensed chromosome →	+0.163	+0.867	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.240	+1.120	<.001	<.001	3	12
OESOPHAGUS	Protein localization to kinetochore →	+0.157	+0.861	<.001	<.001	3	12
BREAST	Protein branched polyubiquitination →	+0.135	+1.239	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,486 associations by consensus.

7-methylguanosine mRNA capping by COMMD8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →