Across TCGA pan-cancer cohorts, COMMD6 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COMMD6 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COMMD6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated COMMD6 expression acts as an unfavorable survival marker.

UCEC, COAD, and BLCA are the cancer types where COMMD6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.662	0.928	<.001	36	view →
COAD	OS	Median	All	0.089	0.871	<.001	36	view →
BLCA	OS	Median	All	0.189	0.609	.017	15	view →
SKCM	OS	Median	II,III,IV	0.245	0.731	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: COMMD6 tumor-vs-normal RNA expression · all COMMD6 data types