COMMD4

Across TCGA pan-cancer cohorts, COMMD4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated COMMD4 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COMMD4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COMMD4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where COMMD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.425	0.902	.018	8	view →
CCRCC	OS	Median	III,IV	1.000	0.389	.035	6	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.314	.006	4	view →
PDAC	DFS	Tertile	IV	0.199	0.752	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

COMMD4–UCEC (DFS)

Open the UCEC breakdown →