COMMD4

Across TCGA patient cohorts, COMMD4 mutation is significantly associated with the RNA expression of many other genes, with 709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD4-associated genes across cancer lineages are LAT2, RN7SL745P, and CD207. Each is linked with COMMD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD4-to-partner and partner-to-COMMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAT2 grouped by COMMD4-low versus COMMD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD4→partner) and Y-score (partner→COMMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LAT2 →	+0.487	+2.233	.005	.006	3	2
COAD	RN7SL745P →	+0.275	+3.321	.001	.004	3	2
UCEC	CD207 →	-0.916	-2.906	.002	.002	3	2
UCEC	LINC00158 →	+0.206	+2.491	<.001	.003	3	2
UCEC	RNU6-1263P →	+0.333	+1.919	.002	.009	3	2
UCEC	KRT18P5 →	+0.361	+3.234	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 709 associations by consensus.

LAT2 by COMMD4 expression — UCEC

Explore this box plot interactively →