COMMD4

Across TCGA patient cohorts, COMMD4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD4-associated genes across cancer lineages are PCNA, PRDX1, and ERK2. Each is linked with COMMD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD4-to-partner and partner-to-COMMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by COMMD4-low versus COMMD4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD4→partner) and Y-score (partner→COMMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.326	+3.000	.001	.035	3	2
UCEC	PRDX1 →	+0.208	+3.169	.021	.019	3	2
UCEC	ERK2 →	+0.166	+2.321	.049	.034	3	1
UCEC	Fibronectin →	-0.338	-2.446	.019	.018	3	1
UCEC	IGFBP2 →	-0.776	-2.321	.006	.034	3	1
UCEC	JNK2 →	+0.181	+2.115	.037	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PCNA by COMMD4 expression — SKCM

Explore this box plot interactively →