COMMD4

Across TCGA cell cohorts, COMMD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,164 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible COMMD4-associated GO terms across cancer lineages are DNA replication proofreading, DNA replication checkpoint signaling, and Spindle elongation. Each is linked with COMMD4 in more than 13 cancer types. Because this analysis shows association rather than direction, both COMMD4-to-partner and partner-to-COMMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication proofreading grouped by COMMD4-low versus COMMD4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD4→partner) and Y-score (partner→COMMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNA replication proofreading →	+0.133	+1.075	.003	.005	3	14
SKIN	DNA replication checkpoint signaling →	+0.149	+0.951	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Spindle elongation →	+0.225	+1.030	.001	.001	3	13
PANCREAS	Regulation of meiosis I →	+0.144	+0.630	.002	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Mitotic sister chromatid cohesion →	+0.140	+1.070	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	DTMP biosynthetic process →	+0.222	+0.890	.004	.004	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,164 associations by consensus.

DNA replication proofreading by COMMD4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →