COMMD3

Across TCGA pan-cancer cohorts, COMMD3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated COMMD3 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher COMMD3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated COMMD3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where COMMD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.274	1.000	.001	48	view →
LSCC	DFS	Quartile	III,IV	0.406	0.918	.001	18	view →
HNSC	OS	Tertile	II,III,IV	0.766	0.919	.014	8	view →
LUAD	OS	Tertile	III,IV	1.000	0.423	.019	5	view →
OV	DFS	Median	All	0.859	1.000	.032	4	view →
PDAC	OS	Tertile	III,IV	0.571	0.891	.013	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

COMMD3–UCEC (DFS)

Open the UCEC breakdown →