COMMD3

Across TCGA patient cohorts, COMMD3 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COMMD3-associated genes across cancer lineages are MBD3L3, PANDAR, and RNU6-822P. Each is linked with COMMD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD3-to-partner and partner-to-COMMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by COMMD3-low versus COMMD3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD3→partner) and Y-score (partner→COMMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1
UCEC	PANDAR →	+0.035	+2.933	.005	.006	3	1
UCEC	RNU6-822P →	+0.259	+3.621	.002	.003	3	1
UCEC	RNU1-93P →	+0.292	+3.771	.001	.002	3	1
UCEC	RNU1-100P →	+0.429	+2.911	.001	.003	3	1
UCEC	MT1CP →	+0.450	+2.964	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MBD3L3 by COMMD3 expression — COAD

Explore this box plot interactively →