COMMD2

Across TCGA patient cohorts, COMMD2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,891 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible COMMD2-associated genes across cancer lineages are GPR17, ARMCX4, and MMP19. Each is linked with COMMD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both COMMD2-to-partner and partner-to-COMMD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, COMMD2 versus GPR17 in LSCC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD2→partner) and Y-score (partner→COMMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPR17 →	+0.576	+0.210	<.001	<.001	3	4
LUAD	ARMCX4 →	+0.486	+0.167	<.001	<.001	3	4
GBM	MMP19 →	+0.714	+0.121	.005	.008	2	4
LSCC	ADAMTS17 →	+0.603	+0.129	<.001	.002	3	3
BRCA	MARCHF11 →	-0.484	-0.133	<.001	.007	3	3
BRCA	C13orf46 →	+0.552	+0.189	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,891 associations by consensus.

COMMD2 vs GPR17 — LSCC

Explore this scatter interactively →