COMMD2

Across TCGA patient cohorts, COMMD2 mutation is significantly associated with the RNA expression of many other genes, with 87 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible COMMD2-associated genes across cancer lineages are TSPY12P, RNU6-33P, and RNU6-1110P. Each is linked with COMMD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both COMMD2-to-partner and partner-to-COMMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY12P grouped by COMMD2-low versus COMMD2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COMMD2→partner) and Y-score (partner→COMMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TSPY12P →	+0.067	+5.219	<.001	.002	3	2
UCEC	RNU6-33P →	+0.838	+3.884	<.001	.002	3	2
SKCM	RNU6-1110P →	+0.989	+3.265	<.001	.009	3	1
SKCM	HPYR1 →	+0.049	+3.408	.001	.009	3	1
SKCM	CDH12P1 →	+0.083	+4.199	<.001	.009	3	1
SKCM	LINC02442 →	+0.066	+3.766	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

TSPY12P by COMMD2 expression — SKCM

Explore this box plot interactively →