Across TCGA patient cohorts, COLQ mutation is significantly associated with the RNA expression of many other genes, with 3,298 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible COLQ-associated genes across cancer lineages are CHAF1B, ICMT, and GAS2L1. Each is linked with COLQ in more than 2 cancer types. Because this analysis shows association rather than direction, both COLQ-to-partner and partner-to-COLQ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (COLQ→partner) and Y-score (partner→COLQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1B →	+0.646	+4.000	<.001	<.001	3	3
UCEC	ICMT →	+0.405	+2.871	.001	.001	3	3
SKCM	GAS2L1 →	+0.764	+2.591	<.001	.006	3	3
HNSC	RNA5SP229 →	+0.427	+5.069	<.001	.008	3	2
BLCA	NATP →	+0.040	+4.147	<.001	.009	3	2
BLCA	MIR378E →	+0.240	+4.618	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,298 associations by consensus.

Exploration

COLQ survival (RNA) · tumor vs normal (RNA) · all COLQ data types